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Tuning the serum persistence of human serum albumin domain III:diabody fusion proteins
The long circulation persistence of human serum albumin (HSA) is enabled by its domain III (DIII) interaction with the neonatal Fc receptor (FcRn). A protein scaffold based on HSA DIII was designed. To modify the serum half life of the scaffold, residues H535, H510, and H464 were individually mutate...
Tallennettuna:
| Päätekijät: | , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Oxford University Press
2010
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2935312/ https://ncbi.nlm.nih.gov/pubmed/20802234 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzq054 |
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