Engineered humanized diabodies for microPET imaging of prostate stem cell antigen-expressing tumors

We have previously demonstrated preclinical in vivo targeting of prostate stem cell antigen (PSCA) using a humanized anti-PSCA 2B3 monoclonal antibody (mAb). However, humanization resulted in 5-fold loss of apparent affinity relative to the parental mAb (1 nM). In this study, diabodies (scFv dimers...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Leyton, Jeffrey V., Olafsen, Tove, Sherman, Mark A., Bauer, Karl B., Aghajanian, Patrick, Reiter, Robert E., Wu, Anna M.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2009
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2644405/
https://ncbi.nlm.nih.gov/pubmed/18957406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzn055
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