Tuning the serum persistence of human serum albumin domain III:diabody fusion proteins

The long circulation persistence of human serum albumin (HSA) is enabled by its domain III (DIII) interaction with the neonatal Fc receptor (FcRn). A protein scaffold based on HSA DIII was designed. To modify the serum half life of the scaffold, residues H535, H510, and H464 were individually mutate...

Full description

Saved in:
Bibliographic Details
Main Authors: Kenanova, Vania E., Olafsen, Tove, Salazar, Felix B., Williams, Lawrence E., Knowles, Scott, Wu, Anna M.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2010
Subjects:
Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935312/
https://ncbi.nlm.nih.gov/pubmed/20802234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzq054
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items