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Mechanistic Investigations of Human Reticulocyte 15- and Platelet 12-Lipoxygenases with Arachidonic Acid

Human reticulocyte 15-lipoxygenase-1 (15-hLO-1) and human platelet 12-lipoxygenase (12-hLO) have been implicated in a number of diseases, with differences in their relative activity potentially playing a central role. In the current paper, we characterize the catalytic mechanism of these two enzymes...

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Bibliografiske detaljer
Main Authors: Wecksler, Aaron T., Jacquot, Cyril, van der Donk, Wilfred A., Holman, Theodore R.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935259/
https://ncbi.nlm.nih.gov/pubmed/19469483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi802332j
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