Aerosol Therapy with Colistin Methanesulfonate: a Biopharmaceutical Issue Illustrated in Rats

The aim of this study was to evaluate the biopharmaceutical behavior of colistin methanesulfonate (CMS) with special focus on colistin presystemic formation after CMS nebulization in rats. CMS was administered (15 mg·kg(−1) of body weight) either intravenously for systemic pharmacokinetic studies (n...

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Bibliographic Details
Main Authors: Marchand, Sandrine, Gobin, Patrice, Brillault, Julien, Baptista, Sara, Adier, Christophe, Olivier, Jean-Christophe, Mimoz, Olivier, Couet, William
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2934989/
https://ncbi.nlm.nih.gov/pubmed/20547787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00411-10
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