Comparison of Intrapulmonary and Systemic Pharmacokinetics of Colistin Methanesulfonate (CMS) and Colistin after Aerosol Delivery and Intravenous Administration of CMS in Critically Ill Patients

Colistin is an old antibiotic that has recently gained a considerable renewal of interest for the treatment of pulmonary infections due to multidrug-resistant Gram-negative bacteria. Nebulization seems to be a promising form of administration, but colistin is administered as an inactive prodrug, col...

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Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: Boisson, Matthieu, Jacobs, Matthieu, Grégoire, Nicolas, Gobin, Patrice, Marchand, Sandrine, Couet, William, Mimoz, Olivier
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249558/
https://ncbi.nlm.nih.gov/pubmed/25267660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03510-14
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