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Comparison of Intrapulmonary and Systemic Pharmacokinetics of Colistin Methanesulfonate (CMS) and Colistin after Aerosol Delivery and Intravenous Administration of CMS in Critically Ill Patients

Colistin is an old antibiotic that has recently gained a considerable renewal of interest for the treatment of pulmonary infections due to multidrug-resistant Gram-negative bacteria. Nebulization seems to be a promising form of administration, but colistin is administered as an inactive prodrug, col...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Boisson, Matthieu, Jacobs, Matthieu, Grégoire, Nicolas, Gobin, Patrice, Marchand, Sandrine, Couet, William, Mimoz, Olivier
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249558/
https://ncbi.nlm.nih.gov/pubmed/25267660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03510-14
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