Comparison of Intrapulmonary and Systemic Pharmacokinetics of Colistin Methanesulfonate (CMS) and Colistin after Aerosol Delivery and Intravenous Administration of CMS in Critically Ill Patients

Colistin is an old antibiotic that has recently gained a considerable renewal of interest for the treatment of pulmonary infections due to multidrug-resistant Gram-negative bacteria. Nebulization seems to be a promising form of administration, but colistin is administered as an inactive prodrug, col...

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Bibliographische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Boisson, Matthieu, Jacobs, Matthieu, Grégoire, Nicolas, Gobin, Patrice, Marchand, Sandrine, Couet, William, Mimoz, Olivier
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249558/
https://ncbi.nlm.nih.gov/pubmed/25267660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03510-14
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