Comparison of Intrapulmonary and Systemic Pharmacokinetics of Colistin Methanesulfonate (CMS) and Colistin after Aerosol Delivery and Intravenous Administration of CMS in Critically Ill Patients

Colistin is an old antibiotic that has recently gained a considerable renewal of interest for the treatment of pulmonary infections due to multidrug-resistant Gram-negative bacteria. Nebulization seems to be a promising form of administration, but colistin is administered as an inactive prodrug, col...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Boisson, Matthieu, Jacobs, Matthieu, Grégoire, Nicolas, Gobin, Patrice, Marchand, Sandrine, Couet, William, Mimoz, Olivier
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2014
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249558/
https://ncbi.nlm.nih.gov/pubmed/25267660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03510-14
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