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Canonical and alternate functions of the microRNA biogenesis machinery
The canonical microRNA (miRNA) biogenesis pathway requires two RNaseIII enzymes: Drosha and Dicer. To understand their functions in mammals in vivo, we engineered mice with germline or tissue-specific inactivation of the genes encoding these two proteins. Changes in proteomic and transcriptional pro...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Cold Spring Harbor Laboratory Press
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2932976/ https://ncbi.nlm.nih.gov/pubmed/20713509 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1953310 |
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