Diverse endonucleolytic cleavage sites in the mammalian transcriptome depend upon microRNAs, Drosha, and additional nucleases

The lifespan of a mammalian mRNA is determined, in part, by the binding of regulatory proteins and small RNA-guided complexes. The conserved endonuclease activity of Argonaute2 requires extensive complementarity between a small RNA and its target and is not used by animal microRNAs, which pair with...

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Bibliographic Details
Main Authors: Karginov, Fedor V., Cheloufi, Sihem, Chong, Mark M.W., Stark, Alexander, Smith, Andrew D., Hannon, Gregory J.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2914474/
https://ncbi.nlm.nih.gov/pubmed/20620951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.06.001
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