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Canonical and alternate functions of the microRNA biogenesis machinery

The canonical microRNA (miRNA) biogenesis pathway requires two RNaseIII enzymes: Drosha and Dicer. To understand their functions in mammals in vivo, we engineered mice with germline or tissue-specific inactivation of the genes encoding these two proteins. Changes in proteomic and transcriptional pro...

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Détails bibliographiques
Auteurs principaux: Chong, Mark M.W., Zhang, Guoan, Cheloufi, Sihem, Neubert, Thomas A., Hannon, Gregory J., Littman, Dan R.
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2932976/
https://ncbi.nlm.nih.gov/pubmed/20713509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1953310
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