Synthesis and Structure–Activity Relationships of N-(2-Oxo-3-oxetanyl)amides as N-Acylethanolamine-hydrolyzing Acid Amidase Inhibitors

The fatty acid ethanolamides (FAEs) are a family of bioactive lipid mediators that include the endogenous agonist of peroxisome proliferator-activated receptor-α, palmitoylethanolamide (PEA). FAEs are hydrolyzed intracellularly by either fatty acid amide hydrolase or N-acylethanolamine-hydrolyzing a...

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Main Authors: Solorzano, Carlos, Antonietti, Francesca, Duranti, Andrea, Tontini, Andrea, Rivara, Silvia, Lodola, Alessio, Vacondio, Federica, Tarzia, Giorgio, Piomelli, Daniele, Mor, Marco
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2932887/
https://ncbi.nlm.nih.gov/pubmed/20604568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100582w
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