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Role of CaMKII in RyR Leak, EC Coupling and Action Potential Duration: A Computational Model
During heart failure, the ability of the sarcoplasmic reticulum (SR) to store Ca(2+) is severely impaired resulting in abnormal Ca(2+) cycling and excitation-contraction (EC) coupling. Recently, it has been proposed that “leaky” ryanodine receptors (RyRs) contribute to diminished Ca(2+) levels in th...
Kaydedildi:
| Asıl Yazarlar: | , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2010
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2932814/ https://ncbi.nlm.nih.gov/pubmed/20655925 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2010.07.011 |
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