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Role of CaMKII in RyR Leak, EC Coupling and Action Potential Duration: A Computational Model

During heart failure, the ability of the sarcoplasmic reticulum (SR) to store Ca(2+) is severely impaired resulting in abnormal Ca(2+) cycling and excitation-contraction (EC) coupling. Recently, it has been proposed that “leaky” ryanodine receptors (RyRs) contribute to diminished Ca(2+) levels in th...

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Bibliografische gegevens
Hoofdauteurs: Hashambhoy, Yasmin L., Greenstein, Joseph L., Winslow, Raimond L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2932814/
https://ncbi.nlm.nih.gov/pubmed/20655925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2010.07.011
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