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Amphiphile regulation of ion channel function by changes in the bilayer spring constant

Many drugs are amphiphiles that, in addition to binding to a particular target protein, adsorb to cell membrane lipid bilayers and alter intrinsic bilayer physical properties (e.g., bilayer thickness, monolayer curvature, and elastic moduli). Such changes can modulate membrane protein function by al...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Lundbæk, Jens A., Koeppe, Roger E., Andersen, Olaf S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2932597/
https://ncbi.nlm.nih.gov/pubmed/20713738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1007455107
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