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DNA damage signaling in response to double-strand breaks during mitosis

The signaling cascade initiated in response to DNA double-strand breaks (DSBs) has been extensively investigated in interphase cells. Here, we show that mitotic cells treated with DSB-inducing agents activate a “primary” DNA damage response (DDR) comprised of early signaling events, including activa...

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Detalles Bibliográficos
Main Authors: Giunta, Simona, Belotserkovskaya, Rimma, Jackson, Stephen P.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930281/
https://ncbi.nlm.nih.gov/pubmed/20660628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200911156
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