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Give me a break, but not in mitosis: The mitotic DNA damage response marks DNA double strand breaks with early signaling events

DNA double-strand breaks (DSBs) are extremely cytotoxic lesions with a single unrepaired DSB being sufficient to induce cell death. A complex signaling cascade, termed the DNA damage response (DDR), is in place to deal with such DNA lesions and maintain genome stability. Recent work by us and others...

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Autores principales: Giunta, Simona, Jackson, Stephen P
Formato: Artigo
Lenguaje:Inglês
Publicado: Landes Bioscience 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117133/
https://ncbi.nlm.nih.gov/pubmed/21412056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.8.15334
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