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Catalysis of lysine 48-specific ubiquitin chain assembly by residues in E2 and ubiquitin

Protein ubiquitination is catalyzed by ubiquitin-conjugating enzymes (E2s) in collaboration with ubiquitin-protein ligases (E3s). This process depends on nucleophilic attack by a substrate lysine on a thioester bond linking the C-terminus of ubiquitin to a cysteine in the E2 active site. Different E...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Rodrigo-Brenni, Monica C., Foster, Scott A., Morgan, David O.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929935/
https://ncbi.nlm.nih.gov/pubmed/20797627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.07.027
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