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Catalysis of lysine 48-specific ubiquitin chain assembly by residues in E2 and ubiquitin
Protein ubiquitination is catalyzed by ubiquitin-conjugating enzymes (E2s) in collaboration with ubiquitin-protein ligases (E3s). This process depends on nucleophilic attack by a substrate lysine on a thioester bond linking the C-terminus of ubiquitin to a cysteine in the E2 active site. Different E...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2929935/ https://ncbi.nlm.nih.gov/pubmed/20797627 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.07.027 |
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