Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis

Cystic fibrosis (CF) is a recessive disease that affects multiple organs. It is caused by mutations in CFTR. Animal modeling of this disease has been challenging, with species- and strain-specific differences in organ biology and CFTR function influencing the emergence of disease pathology. Here, we...

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Autori principali: Sun, Xingshen, Sui, Hongshu, Fisher, John T., Yan, Ziying, Liu, Xiaoming, Cho, Hyung-Ju, Joo, Nam Soo, Zhang, Yulong, Zhou, Weihong, Yi, Yaling, Kinyon, Joann M., Lei-Butters, Diana C., Griffin, Michelle A., Naumann, Paul, Luo, Meihui, Ascher, Jill, Wang, Kai, Frana, Timothy, Wine, Jeffrey J., Meyerholz, David K., Engelhardt, John F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2010
Soggetti:
Technical Advance
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929732/
https://ncbi.nlm.nih.gov/pubmed/20739752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43052
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