Adeno-associated virus–targeted disruption of the CFTR gene in cloned ferrets

Somatic cell gene targeting combined with nuclear transfer cloning presents tremendous potential for the creation of new, large-animal models of human diseases. Mouse disease models often fail to reproduce human phenotypes, underscoring the need for the generation and study of alternative disease mo...

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Bibliographische Detailangaben
Hauptverfasser: Sun, Xingshen, Yan, Ziying, Yi, Yaling, Li, Ziyi, Lei, Diana, Rogers, Christopher S., Chen, Juan, Zhang, Yulong, Welsh, Michael J., Leno, Gregory H., Engelhardt, John F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2008
Schlagworte:
Technical Advance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2263147/
https://ncbi.nlm.nih.gov/pubmed/18324338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34599
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