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Pancreas-specific G(s)α deficiency has divergent effects on pancreatic α and β cell proliferation

The ubiquitously expressed G protein α-subunit G(s)α mediates the intracellular cAMP response to glucagon-like peptide 1 (GLP1) and other incretin hormones in pancreatic islet cells. We have shown previously that mice with β cell-specific G(s)α deficiency (βGsKO) develop severe early-onset insulin-d...

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Bibliografski detalji
Glavni autori: Xie, Tao, Chen, Min, Weinstein, Lee S.
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929693/
https://ncbi.nlm.nih.gov/pubmed/20543009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1677/JOE-10-0030
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