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Pancreas-specific G(s)α deficiency has divergent effects on pancreatic α and β cell proliferation
The ubiquitously expressed G protein α-subunit G(s)α mediates the intracellular cAMP response to glucagon-like peptide 1 (GLP1) and other incretin hormones in pancreatic islet cells. We have shown previously that mice with β cell-specific G(s)α deficiency (βGsKO) develop severe early-onset insulin-d...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2929693/ https://ncbi.nlm.nih.gov/pubmed/20543009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1677/JOE-10-0030 |
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