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β cell-specific deficiency of the stimulatory G protein α-subunit G(s)α leads to reduced β cell mass and insulin-deficient diabetes
The G protein α-subunit G(s)α is required for hormone-stimulated cAMP generation. In pancreatic β cells, G(s)α mediates the signaling of glucagon-like peptide 1 and other incretin hormones, which are implicated as important regulators of β cell survival and insulin release. Studies have suggested th...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2148335/ https://ncbi.nlm.nih.gov/pubmed/18029451 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0704796104 |
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