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G(s)α deficiency in skeletal muscle leads to reduced muscle mass, fiber-type switching, and glucose intolerance without insulin resistance or deficiency
The ubiquitously expressed G protein α-subunit G(s)α is required for receptor-stimulated intracellular cAMP responses and is an important regulator of energy and glucose metabolism. We have generated skeletal muscle-specific G(s)α-knockout (KO) mice (MGsKO) by mating G(s)α-floxed mice with muscle cr...
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| 主要な著者: | , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Physiological Society
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2670650/ https://ncbi.nlm.nih.gov/pubmed/19158402 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00443.2008 |
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