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G(s)α deficiency in skeletal muscle leads to reduced muscle mass, fiber-type switching, and glucose intolerance without insulin resistance or deficiency

The ubiquitously expressed G protein α-subunit G(s)α is required for receptor-stimulated intracellular cAMP responses and is an important regulator of energy and glucose metabolism. We have generated skeletal muscle-specific G(s)α-knockout (KO) mice (MGsKO) by mating G(s)α-floxed mice with muscle cr...

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Bibliografski detalji
Glavni autori: Chen, Min, Feng, Han-Zhong, Gupta, Divakar, Kelleher, James, Dickerson, Kathryn E., Wang, Jie, Hunt, Desmond, Jou, William, Gavrilova, Oksana, Jin, Jian-Ping, Weinstein, Lee S.
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670650/
https://ncbi.nlm.nih.gov/pubmed/19158402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00443.2008
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