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Functional studies of Plasmodium falciparum dipeptidyl aminopeptidase I (DPAP1) using small molecule inhibitors and active site probes

The widespread resistance of malaria parasites to all affordable drugs has made the identification of new targets urgent. Dipeptidyl aminopeptidases (DPAPs) represent potentially valuable new targets that are involved in hemoglobin degradation (DPAP1) and parasite egress (DPAP3). Here we use activit...

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Bibliographische Detailangaben
Hauptverfasser: Deu, Edgar, Leyva, Melissa J., Albrow, Victoria E., Rice, Mark J., Ellman, Jonathan A., Bogyo, Matthew
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929396/
https://ncbi.nlm.nih.gov/pubmed/20797610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.06.007
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