Plasmodium Dipeptidyl Aminopeptidases as Malaria Transmission-Blocking Drug Targets

The Plasmodium falciparum and P. berghei genomes each contain three dipeptidyl aminopeptidase (dpap) homologs. dpap1 and -3 are critical for asexual growth, but the role of dpap2, the gametocyte-specific homolog, has not been tested. If DPAPs are essential for transmission as well as asexual growth,...

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Main Authors: Tanaka, Takeshi Q, Deu, Edgar, Molina-Cruz, Alvaro, Ashburne, Michael J., Ali, Omar, Suri, Amreena, Kortagere, Sandhya, Bogyo, Matthew, Williamson, Kim C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811399/
https://ncbi.nlm.nih.gov/pubmed/23836185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02495-12
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