Identification of Plasmodium dipeptidyl aminopeptidase allosteric inhibitors by high throughput screening

Dipeptidyl aminopeptidases (DPAPs) are cysteine proteases that cleave dipeptides from the N-terminus of protein substrates and have been shown to play important roles in many pathologies including parasitic diseases such as malaria, toxoplasmosis and Chagas’s disease. Inhibitors of the mammalian hom...

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Publicat a:PLoS One
Autors principals: Sanchez, Mateo I., de Vries, Laura E., Lehmann, Christine, Lee, Jeong T., Ang, Kenny K., Wilson, Christopher, Chen, Steven, Arkin, Michelle R., Bogyo, Matthew, Deu, Edgar
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6919601/
https://ncbi.nlm.nih.gov/pubmed/31851699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0226270
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