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Targeting Bcl-2-mediated cell death as a novel therapy in pancreatic cancer
BACKGROUND: Bcl-2 is an essential regulator of programmed cell death (PCD). Overexpression of Bcl-2 is common in pancreatic cancer; the high levels have been shown to correlate with resistance to PCD. This resistance is mediated by binding of Bcl-2 via its BH-3 domain to diverse proteins including t...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2929291/ https://ncbi.nlm.nih.gov/pubmed/20452611 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jss.2010.02.021 |
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