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Targeting Bcl-2-mediated cell death as a novel therapy in pancreatic cancer

BACKGROUND: Bcl-2 is an essential regulator of programmed cell death (PCD). Overexpression of Bcl-2 is common in pancreatic cancer; the high levels have been shown to correlate with resistance to PCD. This resistance is mediated by binding of Bcl-2 via its BH-3 domain to diverse proteins including t...

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Main Authors: Muilenburg, Diego J., Coates, Jodi M., Virudachalam, Subbulakshmi, Bold, Richard J.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929291/
https://ncbi.nlm.nih.gov/pubmed/20452611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jss.2010.02.021
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