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BH3-only protein BIK induces caspase-independent cell death with autophagic features in Bcl-2 null cells
The BH3-only protein BIK normally induces apoptotic cell death. Here, we have investigated the role of BCL-2 in BIK-induced cell death using Bcl-2(+/+) and Bcl-2(−/−) mouse embryo fibroblasts. Ectopic expression of BIK in Bcl-2(−/−) cells resulted in enhanced cell death compared to Bcl-2(+/+) cells....
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2928058/ https://ncbi.nlm.nih.gov/pubmed/17873911 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.onc.1210783 |
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