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BIK-the founding member of the BH3-only family proteins: mechanisms of cell death and role in cancer and pathogenic processes
BIK is the founding member of the BH3-only family pro-apoptotic proteins. BIK is predominantly localized in the ER and induces apoptosis through the mitochondrial pathway by mobilizing calcium from the ER to the mitochondria and remodeling the mitochondrial cristae. BIK-mediated apoptosis is mediate...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2928562/ https://ncbi.nlm.nih.gov/pubmed/19641504 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.40 |
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