Human Immune System Development and Rejection of Human Islet Allografts in Spontaneously Diabetic NOD-Rag1(null) IL2rγ(null) Ins2(Akita) Mice

OBJECTIVE: To create an immunodeficient mouse model that spontaneously develops hyperglycemia to serve as a diabetic host for human islets and stem cell–derived β-cells in the absence or presence of a functional human immune system. RESEARCH DESIGN AND METHODS: We backcrossed the Ins2(Akita) mutatio...

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Detalhes bibliográficos
Main Authors: Brehm, Michael A., Bortell, Rita, diIorio, Philip, Leif, Jean, Laning, Joseph, Cuthbert, Amy, Yang, Chaoxing, Herlihy, Mary, Burzenski, Lisa, Gott, Bruce, Foreman, Oded, Powers, Alvin C., Greiner, Dale L., Shultz, Leonard D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2010
Assuntos:
Immunology and Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2927949/
https://ncbi.nlm.nih.gov/pubmed/20570944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0323
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