Human Immune System Development and Rejection of Human Islet Allografts in Spontaneously Diabetic NOD-Rag1(null) IL2rγ(null) Ins2(Akita) Mice

OBJECTIVE: To create an immunodeficient mouse model that spontaneously develops hyperglycemia to serve as a diabetic host for human islets and stem cell–derived β-cells in the absence or presence of a functional human immune system. RESEARCH DESIGN AND METHODS: We backcrossed the Ins2(Akita) mutatio...

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Hauptverfasser: Brehm, Michael A., Bortell, Rita, diIorio, Philip, Leif, Jean, Laning, Joseph, Cuthbert, Amy, Yang, Chaoxing, Herlihy, Mary, Burzenski, Lisa, Gott, Bruce, Foreman, Oded, Powers, Alvin C., Greiner, Dale L., Shultz, Leonard D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2010
Schlagworte:
Immunology and Transplantation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2927949/
https://ncbi.nlm.nih.gov/pubmed/20570944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0323
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