Small molecule disruption of Gβγ signaling inhibits the progression of heart failure

RATIONALE: Excess signaling through cardiac Gβγ subunits is an important component of heart failure (HF) pathophysiology. They recruit elevated levels of cytosolic G-protein coupled receptor kinase 2 (GRK2) to agonist-stimulated β-adrenergic receptors (β-ARs) in HF, leading to chronic β-AR desensiti...

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Bibliografiset tiedot
Päätekijät: Casey, Liam M., Pistner, Andrew R., Belmonte, Stephen L., Migdalovich, Dmitriy, Stolpnik, Olga, Nwakanma, Frances E., Vorobiof, Gabriel, Dunaevsky, Olga, Matavel, Alessandra, Lopes, Coeli M.B., Smrcka, Alan V., Blaxall, Burns C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2010
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924955/
https://ncbi.nlm.nih.gov/pubmed/20576935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.110.217075
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