Small molecule disruption of Gβγ signaling inhibits the progression of heart failure

RATIONALE: Excess signaling through cardiac Gβγ subunits is an important component of heart failure (HF) pathophysiology. They recruit elevated levels of cytosolic G-protein coupled receptor kinase 2 (GRK2) to agonist-stimulated β-adrenergic receptors (β-ARs) in HF, leading to chronic β-AR desensiti...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Casey, Liam M., Pistner, Andrew R., Belmonte, Stephen L., Migdalovich, Dmitriy, Stolpnik, Olga, Nwakanma, Frances E., Vorobiof, Gabriel, Dunaevsky, Olga, Matavel, Alessandra, Lopes, Coeli M.B., Smrcka, Alan V., Blaxall, Burns C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924955/
https://ncbi.nlm.nih.gov/pubmed/20576935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.110.217075
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