Small molecule disruption of Gβγ signaling inhibits the progression of heart failure

RATIONALE: Excess signaling through cardiac Gβγ subunits is an important component of heart failure (HF) pathophysiology. They recruit elevated levels of cytosolic G-protein coupled receptor kinase 2 (GRK2) to agonist-stimulated β-adrenergic receptors (β-ARs) in HF, leading to chronic β-AR desensiti...

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Autors principals: Casey, Liam M., Pistner, Andrew R., Belmonte, Stephen L., Migdalovich, Dmitriy, Stolpnik, Olga, Nwakanma, Frances E., Vorobiof, Gabriel, Dunaevsky, Olga, Matavel, Alessandra, Lopes, Coeli M.B., Smrcka, Alan V., Blaxall, Burns C.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924955/
https://ncbi.nlm.nih.gov/pubmed/20576935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.110.217075
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