Small molecule disruption of Gβγ signaling inhibits the progression of heart failure

RATIONALE: Excess signaling through cardiac Gβγ subunits is an important component of heart failure (HF) pathophysiology. They recruit elevated levels of cytosolic G-protein coupled receptor kinase 2 (GRK2) to agonist-stimulated β-adrenergic receptors (β-ARs) in HF, leading to chronic β-AR desensiti...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Casey, Liam M., Pistner, Andrew R., Belmonte, Stephen L., Migdalovich, Dmitriy, Stolpnik, Olga, Nwakanma, Frances E., Vorobiof, Gabriel, Dunaevsky, Olga, Matavel, Alessandra, Lopes, Coeli M.B., Smrcka, Alan V., Blaxall, Burns C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2010
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924955/
https://ncbi.nlm.nih.gov/pubmed/20576935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.110.217075
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