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Cystamine and Intrabody Co-treatment Confers Additional Benefits in a Fly Model of Huntington’s Disease
Huntington’s disease (HD) is a lethal, neurodegenerative disorder caused by expansion of the polyglutamine repeat in the Huntingtin gene (HTT), leading to mutant protein misfolding, aggregation, and neuronal death. Feeding a Drosophila HD-model cystamine, or expressing a transgene encoding the anti-...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2924926/ https://ncbi.nlm.nih.gov/pubmed/20399860 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2010.04.007 |
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