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UPF1 Association With the Cap-binding Protein, CBP80, Promotes Nonsense-mediated mRNA Decay at Two Distinct Steps
Nonsense-mediated mRNA decay (NMD) is an mRNA surveillance mechanism that in mammals generally occurs upon recognition of a premature termination codon (PTC) during a pioneer round of translation. This round involves newly synthesized mRNA that is bound at its 5’ end by the cap-binding protein (CBP)...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2924619/ https://ncbi.nlm.nih.gov/pubmed/20691628 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.07.004 |
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