Targeting the urokinase plasminogen activator receptor enhances gene transfer to human airway epithelia

Developing gene therapy for cystic fibrosis has been hindered by limited binding and endocytosis of vectors by human airway epithelia. Here we show that the apical membrane of airway epithelia express the urokinase plasminogen activator receptor (uPAR). Urokinase plasminogen activator (uPA), or a 7-...

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書目詳細資料

發表在:	J Clin Invest
Principais autores:	Drapkin, Paola T., O’Riordan, Catherine R., Yi, Su Min, Chiorini, John A., Cardella, Jonathan, Zabner, Joseph, Welsh, Michael J.
格式:	Artigo
語言:	Inglês
出版:	American Society for Clinical Investigation 2000
主題:	Article
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC292456/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10712430/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI8858
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