Apical Localization of the Coxsackie-Adenovirus Receptor by Glycosyl-Phosphatidylinositol Modification Is Sufficient for Adenovirus-Mediated Gene Transfer through the Apical Surface of Human Airway Epithelia

In well-differentiated human airway epithelia, the coxsackie B and adenovirus type 2 and 5 receptor (CAR) resides primarily on the basolateral membrane. This location may explain the observation that gene transfer is inefficient when adenovirus vectors are applied to the apical surface. To further t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Walters, Robert W., van't Hof, Wouter, Yi, Su Min P., Schroth, Mary K., Zabner, Joseph, Crystal, Ronald G., Welsh, Michael J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2001
Schlagworte:
Gene Therapy
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC115005/
https://ncbi.nlm.nih.gov/pubmed/11462042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.16.7703-7711.2001
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