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Apical Localization of the Coxsackie-Adenovirus Receptor by Glycosyl-Phosphatidylinositol Modification Is Sufficient for Adenovirus-Mediated Gene Transfer through the Apical Surface of Human Airway Epithelia

In well-differentiated human airway epithelia, the coxsackie B and adenovirus type 2 and 5 receptor (CAR) resides primarily on the basolateral membrane. This location may explain the observation that gene transfer is inefficient when adenovirus vectors are applied to the apical surface. To further t...

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Published in:J Virol
Main Authors: Walters, Robert W., van't Hof, Wouter, Yi, Su Min P., Schroth, Mary K., Zabner, Joseph, Crystal, Ronald G., Welsh, Michael J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2001
Subjects:
Gene Therapy
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC115005/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11462042/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.16.7703-7711.2001
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