Incorporation of adenovirus in calcium phosphate precipitates enhances gene transfer to airway epithelia in vitro and in vivo.

Adenovirus (Ad)-mediated gene transfer to airway epithelia is inefficient because the apical membrane lacks the receptor activity to bind adenovirus fiber protein. Calcium phosphate (CaPi) precipitates have been used to deliver plasmid DNA to cultured cell lines. However, such precipitates are not e...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Fasbender, A, Lee, J H, Walters, R W, Moninger, T O, Zabner, J, Welsh, M J
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 1998
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC509080/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9649572/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI2732
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