A shortened adeno-associated virus expression cassette for CFTR gene transfer to cystic fibrosis airway epithelia

Adeno-associated viruses (AAVs) such as AAV5 that transduce airway epithelia from the apical surface are attractive vectors for gene transfer in cystic fibrosis (CF). However, their utility in CF has been limited because packaging of the insert becomes inefficient when its length exceeds ≈4,900–5,00...

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Detalhes bibliográficos
Main Authors: Ostedgaard, Lynda S., Rokhlina, Tatiana, Karp, Philip H., Lashmit, Philip, Afione, Sandra, Schmidt, Michael, Zabner, Joseph, Stinski, Mark F., Chiorini, Jay A., Welsh, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC549485/
https://ncbi.nlm.nih.gov/pubmed/15703296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409845102
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