Targeting the urokinase plasminogen activator receptor enhances gene transfer to human airway epithelia

Developing gene therapy for cystic fibrosis has been hindered by limited binding and endocytosis of vectors by human airway epithelia. Here we show that the apical membrane of airway epithelia express the urokinase plasminogen activator receptor (uPAR). Urokinase plasminogen activator (uPA), or a 7-...

ver descrição completa

Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Drapkin, Paola T., O’Riordan, Catherine R., Yi, Su Min, Chiorini, John A., Cardella, Jonathan, Zabner, Joseph, Welsh, Michael J.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 2000
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC292456/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10712430/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI8858
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!