Targeting the urokinase plasminogen activator receptor enhances gene transfer to human airway epithelia

Developing gene therapy for cystic fibrosis has been hindered by limited binding and endocytosis of vectors by human airway epithelia. Here we show that the apical membrane of airway epithelia express the urokinase plasminogen activator receptor (uPAR). Urokinase plasminogen activator (uPA), or a 7-...

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Main Authors: Drapkin, Paola T., O’Riordan, Catherine R., Yi, Su Min, Chiorini, John A., Cardella, Jonathan, Zabner, Joseph, Welsh, Michael J.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2000
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC292456/
https://ncbi.nlm.nih.gov/pubmed/10712430
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