Targeting the urokinase plasminogen activator receptor enhances gene transfer to human airway epithelia

Developing gene therapy for cystic fibrosis has been hindered by limited binding and endocytosis of vectors by human airway epithelia. Here we show that the apical membrane of airway epithelia express the urokinase plasminogen activator receptor (uPAR). Urokinase plasminogen activator (uPA), or a 7-...

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Pubblicato in:	J Clin Invest
Autori principali:	Drapkin, Paola T., O’Riordan, Catherine R., Yi, Su Min, Chiorini, John A., Cardella, Jonathan, Zabner, Joseph, Welsh, Michael J.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 2000
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC292456/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10712430/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI8858
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