Targeting the urokinase plasminogen activator receptor enhances gene transfer to human airway epithelia

Developing gene therapy for cystic fibrosis has been hindered by limited binding and endocytosis of vectors by human airway epithelia. Here we show that the apical membrane of airway epithelia express the urokinase plasminogen activator receptor (uPAR). Urokinase plasminogen activator (uPA), or a 7-...

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Bibliografske podrobnosti

izdano v:	J Clin Invest
Principais autores:	Drapkin, Paola T., O’Riordan, Catherine R., Yi, Su Min, Chiorini, John A., Cardella, Jonathan, Zabner, Joseph, Welsh, Michael J.
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Clinical Investigation 2000
Teme:	Article
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC292456/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10712430/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI8858
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