The Dnmt3a PWWP Domain Reads Histone 3 Lysine 36 Trimethylation and Guides DNA Methylation

The Dnmt3a DNA methyltransferase contains in its N-terminal part a PWWP domain that is involved in chromatin targeting. Here, we have investigated the interaction of the PWWP domain with modified histone tails using peptide arrays and show that it specifically recognizes the histone 3 lysine 36 trim...

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Bibliografiske detaljer
Main Authors: Dhayalan, Arunkumar, Rajavelu, Arumugam, Rathert, Philipp, Tamas, Raluca, Jurkowska, Renata Z., Ragozin, Sergey, Jeltsch, Albert
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
DNA and Chromosomes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924014/
https://ncbi.nlm.nih.gov/pubmed/20547484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.089433
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