The Dnmt3a PWWP Domain Reads Histone 3 Lysine 36 Trimethylation and Guides DNA Methylation

The Dnmt3a DNA methyltransferase contains in its N-terminal part a PWWP domain that is involved in chromatin targeting. Here, we have investigated the interaction of the PWWP domain with modified histone tails using peptide arrays and show that it specifically recognizes the histone 3 lysine 36 trim...

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Bibliografske podrobnosti
Main Authors: Dhayalan, Arunkumar, Rajavelu, Arumugam, Rathert, Philipp, Tamas, Raluca, Jurkowska, Renata Z., Ragozin, Sergey, Jeltsch, Albert
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
DNA and Chromosomes
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924014/
https://ncbi.nlm.nih.gov/pubmed/20547484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.089433
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