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Competitive antagonism of fluorescent gentamicin uptake in the cochlea

Aminoglycosides enter inner ear hair cells via apical endocytosis, or mechanoelectrical transduction channels, implying that, in vivo, aminoglycosides enter hair cells from endolymph prior to exerting their cytotoxic effect. If so, circulating aminoglycosides likely cross the strial blood-labyrinth...

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Bibliografiska uppgifter
Huvudupphovsmän: Wang, Qi, Kachelmeier, Allan, Steyger, Peter S
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923250/
https://ncbi.nlm.nih.gov/pubmed/20561573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heares.2010.06.008
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