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Competitive antagonism of fluorescent gentamicin uptake in the cochlea

Aminoglycosides enter inner ear hair cells via apical endocytosis, or mechanoelectrical transduction channels, implying that, in vivo, aminoglycosides enter hair cells from endolymph prior to exerting their cytotoxic effect. If so, circulating aminoglycosides likely cross the strial blood-labyrinth...

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Detalhes bibliográficos
Main Authors: Wang, Qi, Kachelmeier, Allan, Steyger, Peter S
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923250/
https://ncbi.nlm.nih.gov/pubmed/20561573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heares.2010.06.008
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