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Acoustic Trauma Increases Cochlear and Hair Cell Uptake of Gentamicin

BACKGROUND: Exposure to intense sound or high doses of aminoglycoside antibiotics can increase hearing thresholds, induce cochlear dysfunction, disrupt hair cell morphology and promote hair cell death, leading to permanent hearing loss. When the two insults are combined, synergistic ototoxicity occu...

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Detalhes bibliográficos
Main Authors: Li, Hongzhe, Wang, Qi, Steyger, Peter S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084257/
https://ncbi.nlm.nih.gov/pubmed/21552569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019130
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