Combinatorial profiling of chromatin-binding modules reveals multi-site discrimination

Specific interactions between post-translational modifications (PTMs) and chromatin-binding proteins are central to the idea of a ‘histone code’. Here, a 5000-member, PTM-randomized, combinatorial peptide library based on the N-terminus of histone H3 was utilized to interrogate multi-site specificit...

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Bibliografski detalji
Glavni autori: Garske, Adam L., Oliver, Samuel S., Wagner, Elise K., Musselman, Catherine A., LeRoy, Gary, Garcia, Benjamin A., Kutateladze, Tatiana G., Denu, John M.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922993/
https://ncbi.nlm.nih.gov/pubmed/20190764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.319
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