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Multivalent recognition of histone tails by the PHD-fingers of CHD5

The chromodomain, helicase, DNA-binding protein 5 (CHD5) is a chromatin remodeling enzyme which is implicated in tumor suppression. In this study, we demonstrate the ability of the CHD5 PHD-fingers to specifically recognize the unmodified N-terminus of histone H3. We use two distinct modified peptid...

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Main Authors: Oliver, Samuel S., Musselman, Catherine A., Srinivasan, Rajini, Svaren, John P., Kutateladze, Tatiana G., Denu, John M.
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518043/
https://ncbi.nlm.nih.gov/pubmed/22834704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3006972
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