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Mechanistic Studies of Sansalvamide A-Amide: An Allosteric Modulator of Hsp90
[Image: see text] Herein, we show that sansalvamide A-amide (San A-amide), a structurally unique molecule, influences a subset of cancer-related pathways involving heat shock protein 90 (Hsp90). We show that San A-amide specifically binds to the N-middle domain of Hsp90 and allosterically disrupts t...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Chemical Society
2010
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| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2922868/ https://ncbi.nlm.nih.gov/pubmed/20730035 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml900003t |
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