Mechanistic Studies of Sansalvamide A-Amide: An Allosteric Modulator of Hsp90

[Image: see text] Herein, we show that sansalvamide A-amide (San A-amide), a structurally unique molecule, influences a subset of cancer-related pathways involving heat shock protein 90 (Hsp90). We show that San A-amide specifically binds to the N-middle domain of Hsp90 and allosterically disrupts t...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Vasko, Robert C., Rodriguez, Rodrigo A., Cunningham, Christian N., Ardi, Veronica C., Agard, David A., McAlpine, Shelli R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2010
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922868/
https://ncbi.nlm.nih.gov/pubmed/20730035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml900003t
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